Aryl uracil inhibitors of hepatitis C virus NS5B polymerase: Synthesis and characterization of analogs with a fused 5,6-bicyclic ring motif

A. Chris Krueger; John T. Randolph; David A. DeGoey; Pamela L. Donner; Charles A. Flentge; Douglas K. Hutchinson; Dachun Liu; Christopher E. Motter; Todd W. Rockway; Rolf Wagner; David W.A. Beno; Gennadiy Koev; Hock B. Lim; Jill M. Beyer; Rubina Mondal; Yaya Liu; Warren M. Kati; Kenton L. Longenecker; Akhteruzzaman Molla; Kent D. Stewart; Clarence J. Maring

doi:10.1016/j.bmcl.2013.04.057

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Aryl uracil inhibitors of hepatitis C virus NS5B polymerase: Synthesis and characterization of analogs with a fused 5,6-bicyclic ring motif

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Aryl uracil inhibitors of hepatitis C virus NS5B polymerase: Synthesis and characterization of analogs with a fused 5,6-bicyclic ring motif

A. Chris Krueger, John T. Randolph, David A. DeGoey, Pamela L. Donner, Charles A. Flentge, Douglas K. Hutchinson, Dachun Liu, Christopher E. Motter, Todd W. Rockway, Rolf Wagner, …

Bioorganic & medicinal chemistry letters, Vol.23(12), pp.3487-3490

15/06/2013

DOI: https://doi.org/10.1016/j.bmcl.2013.04.057

PMID: 23664214

Abstract

Aryl uracil

Hepatitis C

NS5B polymerase inhibitors

The synthesis and structure–activity relationships of a novel aryl uracil series which contains a fused 5,6-bicyclic ring unit for HCV NS5B inhibition is described. Several analogs display replicon cell culture potencies in the low nanomolar range along with excellent rat pharmacokinetic values.

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Title: Aryl uracil inhibitors of hepatitis C virus NS5B polymerase: Synthesis and characterization of analogs with a fused 5,6-bicyclic ring motif
Creators - without role: A. Chris Krueger - AbbVie (United States)
John T. Randolph - AbbVie (United States)
David A. DeGoey - AbbVie (United States)
Pamela L. Donner - AbbVie (United States)
Charles A. Flentge - Knopp Biosciences (United States)
Douglas K. Hutchinson - Danbury Hospital
Dachun Liu - AbbVie (United States)
Christopher E. Motter - University of Illinois Urbana-Champaign
Todd W. Rockway - McHenry County College
Rolf Wagner - AbbVie (United States)
David W.A. Beno - Abbott Nutrition (United States)
Gennadiy Koev - AbbVie (United States)
Hock B. Lim - AbbVie Inc., 1 North Waukegan Road, North Chicago, IL 60064, USA
Jill M. Beyer - AbbVie (United States)
Rubina Mondal - Abbott Fund
Yaya Liu - AbbVie (United States)
Warren M. Kati - AbbVie (United States)
Kenton L. Longenecker - AbbVie (United States)
Akhteruzzaman Molla - AbbVie (United States)
Kent D. Stewart - AbbVie (United States)
Clarence J. Maring - AbbVie (United States)
Publication Details: Bioorganic & medicinal chemistry letters, Vol.23(12), pp.3487-3490
Publisher: Elsevier Ltd
Number of pages: 4
Identifiers: 9911771109846
Academic Unit: Aviation Studies Institute
Language: English
Resource Type: Journal article

Aryl uracil inhibitors of hepatitis C virus NS5B polymerase: Synthesis and characterization of analogs with a fused 5,6-bicyclic ring motif

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