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Do cilia put brakes on the cell cycle?
Journal article   Peer reviewed

Do cilia put brakes on the cell cycle?

Peter K. Jackson and Peter Lawrence Jackson
Nature cell biology, Vol.13(4), pp.340-342
04/2011
PMID: 21460803

Abstract

631/136 631/80/128/1383 631/80/641 631/80/86 Article Biomedical and Life Sciences Cancer Research Cell Biology Developmental Biology General Life Sciences news-and-views Stem Cells
Two papers in this issue show that dynein-binding proteins may regulate the G1–S transition through an effect on cilia. Nde1, a known partner of dynein light chain LC8, controls ciliary length in vitro and in zebrafish, and influences the G1–S progression. The phosphorylation of Tctex1, a dynein light chain, modulates cilia length and accelerates G1–S, thereby regulating proliferation–differentiation decisions in the developing mouse neocortex.

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