Abstract
Biologists are stepping up their efforts in understanding the biological processes that underlie disease pathways in the clinical contexts. This has resulted in a flood of biological and clinical data-genomic sequences, DNAmicroarrays, protein interactions, biomedical images, disease pathways, etc. The rapid adoption of Electronic HealthRecords (EHRs) across healthcare systems, coupled with the capability of linking EHRs to research biorepositories, provides a unique opportunity for conducting large-scale Precision Medicine research. As a result, datamining techniques, for knowledge discovery and deriving data driven insights fromvarious data sources, are increasingly important inmodern biology and healthcare. The purpose of this special section is to bring together the researchers in bioinformatics, healthcare informatics, and datamining to share about their current research, and their visions on future directions.