Nek8 couples renal ciliopathies to DNA damage and checkpoint control

Peter K Jackson; Peter Lawrence Jackson

doi:10.1016/j.molcel.2013.08.013

Back

Nek8 couples renal ciliopathies to DNA damage and checkpoint control

Journal article

Peer reviewed

Nek8 couples renal ciliopathies to DNA damage and checkpoint control

Peter K Jackson and Peter Lawrence Jackson

Molecular cell, Vol.51(4), pp.407-408

22/08/2013

DOI: https://doi.org/10.1016/j.molcel.2013.08.013

PMID: 23973371

Abstract

Animals

Ataxia Telangiectasia Mutated Proteins

Cell Cycle Proteins - metabolism

Cilia - pathology

Cyclin-Dependent Kinases - metabolism

DNA Replication - genetics

Humans

NIMA-Related Kinases

Polycystic Kidney Diseases - pathology

Protein Kinases - metabolism

Protein-Serine-Threonine Kinases - metabolism

S Phase - physiology

In this issue, Choi et al. (2013) discover a molecular link between the Nek8 kinase, mutated in the renal ciliopathy nephronophthisis, and DNA damage control by cyclin A/Cdk2 and ATR-Chk1, providing new ideas for targeted therapies limiting tissue degeneration.

Files and links (1)

url

https://doi.org/10.1016/j.molcel.2013.08.013View

Published (Version of record) Open

Metrics

1 Record Views

Details

Title: Nek8 couples renal ciliopathies to DNA damage and checkpoint control
Creators - without role: Peter K Jackson - Stanford University
Peter Lawrence Jackson - ESD Pillar
Publication Details: Molecular cell, Vol.51(4), pp.407-408
Identifiers: 9912738409846
Academic Unit: ESD Pillar
Language: English
Resource Type: Journal article

Nek8 couples renal ciliopathies to DNA damage and checkpoint control

Abstract

Files and links (1)

Metrics

Details

Singapore University of Technology and Design Social media